{"id":442,"date":"2022-06-02T12:25:22","date_gmt":"2022-06-02T12:25:22","guid":{"rendered":"https:\/\/mgpindia.com\/fend\/?p=442"},"modified":"2022-08-24T15:32:17","modified_gmt":"2022-08-24T15:32:17","slug":"david-alland","status":"publish","type":"post","link":"https:\/\/www.fend-tb.org\/staging\/9960\/david-alland\/","title":{"rendered":"David Alland"},"content":{"rendered":"<p class=\"font_0\"><strong>Dr. Alland<\/strong> is a Professor of Medicine and the Chief of Infectious Disease as well as the Director of the Center for Emerging Pathogens and the Rutgers Regional Biocontainment Laboratories at Rutgers New Jersey Medical School. Dr. Alland is internationally recognized for his pioneering work on the epidemiology, diagnosis, treatment, and molecular evolution of M. tuberculosis (Mtb). His epidemiologic studies in the 1990s showed that drug-resistant Mtb was being transmitted in institutions and the community, impacting national TB control efforts. He then led a 10-year research effort that culminated in the development of the Xpert MTB\/RIF Assay, the first on-demand, point-of-care TB test, and the first replacement for the acid-fast smear to diagnose TB in over 100 years, recommended by the WHO and now used in 130 countries. This work continues in the development of rapid diagnostics for extended TB drug resistance, and bloodstream detection of bioterrorism agents, S. aureus, Candida species, and more recent work on point-of-care diagnostics for COVID-19. Dr. Alland\u2019s group along with the Sassetti laboratory discovered that phase variation in the M. tuberculosis glpK gene produced heritable, but rapidly reversible multi-drug tolerance, and suggested that phase variation may explain why TB requires months of multi-drug treatment. Dr. Alland described the complex interactions of mutations in the Mtb embB, Rv3806c and Rv3792 genes in the evolution of ethambutol resistance. He then translated these observations into innovative drug screens for inhibitors of cell wall biosynthesis and respiration, discovering novel drug candidates targeting Mtb Pks13, KasA and MenG, that are highly effective against stationary phase organisms, which promise to address the unmet need for more rapid effective TB treatment. Dr. Alland became the director of the Public Health Research Institute in February 2020; and then recognizing the gravity of the coming COVID-19 epidemic, Dr. Alland organized the Center for Covid-19 response and pandemic preparedness and became its first Director in March 2020.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>FEND-TB Co-PI<\/p>\n","protected":false},"author":1,"featured_media":436,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"nf_dc_page":"","_et_pb_use_builder":"off","_et_pb_old_content":"<p class=\"font_0\"><strong>Dr. Salgame<\/strong> is a Professor in the Department of Medicine, Center for Emerging and Re-Emerging Pathogens, Rutgers University. She is the Director of the MD\/PhD Program and the Graduate Medical Research Program. Her research focuses on Mycobacterium tuberculosis and host immune mechanisms that protect against infection and progression to disease. Her research team also studies the biology and host response of clinical strains of M. tuberculosis with differing transmissibility. Her group conducts these investigations in humans and animal models. She and her collaborators also perform biomarker studies at several international sites. Dr. Salgame is on the Editorial Board of Infection and Immunity and is also an Associate Editor for PLOS Pathogens. In addition to her research pursuits, Dr. Salgame has managed and led a range of science training programs. She is Program Director on a T32 training grant in Infection, Immunity and Inflammation. She is regularly invited to teach in national and international immunology courses.<\/p>","_et_gb_content_width":"2880","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[50,7],"tags":[],"post_folder":[28],"class_list":["post-442","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-analytical-core","category-rutgers"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>David Alland - FEND-TB<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.fend-tb.org\/david-alland\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"David Alland - FEND-TB\" \/>\n<meta property=\"og:description\" content=\"FEND-TB Co-PI\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.fend-tb.org\/david-alland\/\" \/>\n<meta property=\"og:site_name\" content=\"FEND-TB\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-02T12:25:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-08-24T15:32:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/i0.wp.com\/www.fend-tb.org\/wp-content\/uploads\/2022\/06\/David-Alland.jpg?fit=500%2C667&ssl=1\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"667\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"monicagangoly\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"monicagangoly\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.fend-tb.org\\\/david-alland\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.fend-tb.org\\\/david-alland\\\/\"},\"author\":{\"name\":\"monicagangoly\",\"@id\":\"https:\\\/\\\/www.fend-tb.org\\\/#\\\/schema\\\/person\\\/5e18366039df6d5c7b219324f90179eb\"},\"headline\":\"David Alland\",\"datePublished\":\"2022-06-02T12:25:22+00:00\",\"dateModified\":\"2022-08-24T15:32:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.fend-tb.org\\\/david-alland\\\/\"},\"wordCount\":314,\"image\":{\"@id\":\"https:\\\/\\\/www.fend-tb.org\\\/david-alland\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/i0.wp.com\\\/www.fend-tb.org\\\/staging\\\/9960\\\/wp-content\\\/uploads\\\/2022\\\/06\\\/David-Alland.jpg?fit=500%2C667&ssl=1\",\"articleSection\":[\"Analytical Core\",\"Rutgers\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.fend-tb.org\\\/david-alland\\\/\",\"url\":\"https:\\\/\\\/www.fend-tb.org\\\/david-alland\\\/\",\"name\":\"David Alland - 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