{"id":2046,"date":"2022-07-31T15:46:38","date_gmt":"2022-07-31T15:46:38","guid":{"rendered":"https:\/\/mgpindia.com\/fend\/?page_id=2046"},"modified":"2024-10-08T13:51:26","modified_gmt":"2024-10-08T13:51:26","slug":"pediatric","status":"publish","type":"page","link":"https:\/\/www.fend-tb.org\/staging\/9960\/protocols\/pediatric\/","title":{"rendered":"Pediatric"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.17.4″ _module_preset=”default” background_color=”#F5F0EB” custom_padding=”0px|0px|0px||false|false” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.17.6″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.17.6″ _module_preset=”default” custom_padding=”100px||||false|false” custom_padding_tablet=”30px||||false|false” custom_padding_phone=”20px||||false|false” custom_padding_last_edited=”on|phone” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” header_font=”Roboto|500|||||||” header_text_color=”#000000″ header_font_size=”70px” header_line_height=”1.15em” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n

Pediatric Protocol<\/h1>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/fend-tb.org\/wp-content\/uploads\/2022\/07\/test-cropped.jpg” _builder_version=”4.17.6″ _module_preset=”default” custom_margin=”|-10vw|||false|false” custom_margin_tablet=”|0%|||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|tablet” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row custom_padding_last_edited=”on|phone” _builder_version=”4.16″ _module_preset=”default” background_color=”#FFFFFF” background_image=”https:\/\/fend-tb.org\/wp-content\/uploads\/2022\/02\/high-school_34.png” background_size=”initial” background_position=”top_left” background_repeat=”repeat-x” z_index=”500″ custom_margin=”||||false|false” custom_margin_tablet=”0px||||false|false” custom_margin_last_edited=”off|desktop” custom_padding=”40px|40px|40px|40px|true|true” custom_padding_tablet=”30px|30px|30px|30px|true|true” custom_padding_phone=”20px|20px|20px|20px|true|true” box_shadow_style=”preset3″ box_shadow_vertical=”60px” box_shadow_blur=”60px” box_shadow_spread=”0px” box_shadow_color=”rgba(14,15,43,0.1)” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” custom_padding=”40px||40px||true|false” custom_padding_tablet=”40px||40px||true|false” custom_padding_phone=”40px||40px||true|false” custom_padding_last_edited=”on|desktop” header_font_size_tablet=”55px” header_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n

The World Health Organization now estimates an annual incidence of just over one million pediatric TB cases worldwide. Despite significant advances in TB diagnostics in the last decade, these advances have not critically impacted pediatric TB. The true disease burden is difficult to ascertain as most children with TB are never diagnosed by standard microbiological methods. As a result, under-diagnosis of children with TB is common, specifically in high-burden settings, leading to high childhood mortality, specifically among children < 5 years of age. Moreover, pediatric TB is often only recognized post-mortem.<\/p>\n

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\"\"<\/p>\n

[\/et_pb_text][et_pb_team_member name=”Rinn Song” position=”MD” image_url=”https:\/\/fend-tb.org\/wp-content\/uploads\/2022\/06\/Rinn-Song.jpg” facebook_url=”mailto:rinn.song@paediatrics.ox.ac.uk” _builder_version=”4.17.6″ _module_preset=”default” header_font_size=”16px” body_font_size=”13px” body_line_height=”1.5em” link_option_url=”https:\/\/fend-tb.org\/rinn-song\/” box_shadow_style_image=”preset3″ global_colors_info=”{}”][\/et_pb_team_member][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”4.17.6″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.17.6″ _module_preset=”default” header_font_size_tablet=”55px” header_font_size_last_edited=”off|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n

New approaches to the diagnosis of TB in young children are urgently needed. Among the high-priority needs are:<\/p>\n

    \n
  1. Tests that can be used at the POC<\/li>\n
  2. Non-sputum-based tests<\/li>\n
  3. Tests that can accurately identify the children with TB currently classified as microbiologically negative<\/li>\n<\/ol>\n

    The study concurrently evaluates, optimizes, and develops more sensitive, non-sputum-based diagnostics for children < 5 years of age applicable at POC and proposes an enhanced reference standard that can be applied to unconfirmed as well as confirmed TB.<\/p>\n

    The FEND Pediatric program enrolls participants from 2 in-country sites in Peru and Uganda.<\/p>\n

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    Mulago\/Baylor
    Jinja<\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.fend-tb.org\/staging\/9960\/wp-content\/uploads\/2022\/08\/Peru-map.jpg” url=”https:\/\/fend-tb.org\/sites\/peru\/” use_overlay=”on” overlay_icon_color=”#FFFFFF” hover_overlay_color=”rgba(0,0,0,0.5)” hover_icon=”L||divi||400″ align=”center” disabled_on=”off|off|off” module_class=”pa-image-hover-peru” _builder_version=”4.24.3″ _module_preset=”default” custom_padding=”||||true|true” global_colors_info=”{}” src__hover_enabled=”off|desktop” filter_saturate__hover_enabled=”on|hover” filter_saturate__hover=”100%” filter_brightness__hover_enabled=”on|hover” filter_opacity__hover_enabled=”on|hover” filter_opacity__hover=”100%” src__hover=”https:\/\/fend-tb.org\/wp-content\/uploads\/2022\/02\/musc-logo.png”][\/et_pb_image][et_pb_button button_url=”https:\/\/fend-tb.org\/sites\/peru\/” button_text=”Peru” disabled_on=”off|off|off” _builder_version=”4.24.3″ _module_preset=”default” custom_button=”on” button_text_size=”16px” button_text_color=”#b3b3b3″ button_bg_color=”RGBA(255,255,255,0)” button_border_width=”0px” button_letter_spacing=”2px” button_font=”Roboto|||on|||||” button_icon=”9||divi||400″ button_on_hover=”off” custom_padding=”|||0px|false|false” global_colors_info=”{}” button_text_color__hover_enabled=”on|hover” button_text_color__hover=”#CB5341″ button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”RGBA(255,255,255,0)”][\/et_pb_button][et_pb_text disabled_on=”off|off|off” _builder_version=”4.24.3″ _module_preset=”default” text_font_size=”14px” global_colors_info=”{}”]<\/p>\n

    Cayetano Heredia
    San Bartolome<\/p>\n

    [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.17.4″ _module_preset=”default” background_enable_color=”off” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][et_pb_row module_id=”graphs” _builder_version=”4.27.2″ _module_preset=”default” background_color=”#FFFFFF” custom_padding=”|40px|80px|40px|false|true” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.2″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.2″ _module_preset=”003e9429-8e11-4d9e-968b-8881092bbf81″ header_2_font=”Roboto|500|||||||” header_2_text_align=”center” header_2_text_color=”#000000″ text_orientation=”center” custom_margin=”||0px||false|false” custom_padding=”||30px||false|false” header_2_font_size_tablet=”30px” header_2_font_size_phone=”20px” header_2_font_size_last_edited=”on|desktop” locked=”off” global_colors_info=”{}”]<\/p>\n

    FEND-TB Pediatric Protocol Status<\/h2>\n

    % of Total Enrolled Participants<\/h4>\n

    N = 639<\/p>\n

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    79.46% Confirmed MRS -ve \u2022 29.32% irmed TB case eMRS +ve & MRS +ve \u2022 10.51% Pending additional results
    MRS – Microbiological Reference Standard \u2022 eMRS – Extended Microbiological Reference Standard<\/p>\n

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