Professor Moses Joloba is an infectious diseases expert with a focus on pathogenesis, diagnostics and program implementation using both conventional microbiological and modern molecular approaches. In this regard, he has acquired the necessary training and skills, and he has played a leading role in the strengthening of laboratory services in Uganda and other developing countries. He has now transitioned to the application of bioinformatics and genomic technologies to advance tuberculosis research in Uganda. Initially trained as a physician and later as a Clinical Microbiologist in the United States, Moses returned to Uganda and took a faculty position at the Department of Medical Microbiology, Makerere University. During this time he helped establish a laboratory for the Tuberculosis Research Unit (TBRU) and became its technical director and later a scientific director. A number of laboratory based studies were conducted and published many of which he was the first author; these involved research on early bactericidal activity and quantitative bacillary response to therapy and evaluation of new markers to therapy, as documented in the publications below. In 2000 he enrolled on a Ph.D. program in Molecular Biology at Case Western Reserve University. Upon his return to Uganda in 2004, Moses established key laboratories namely Molecular Biology, Immunology and Mycobacteriology laboratories at Makerere University with support from the NIH and Gates Foundation. Also, he was appointed Director of, the National Tuberculosis Reference laboratory (NTRL), now a supranational laboratory. The NTRL is internationally accredited (ISO15819) and supports 1300 laboratories in Uganda and 18 NTRLs in other sub-Saharan countries. he pioneered a TB sample Referral system that has now been integrated to transport specimen for other diseases. Moses is the Chair of the World bank funded East African Public Health Lab-networking group that aims to establish in East Africa, high quality, accessible public health laboratories for the diagnosis and surveillance of TB and other communicable diseases. He participates in North-to-South and South-to-South collaborations involving laboratory-based health research. He has successfully competed for extramural research support (obtained 10 grants so far) and published over 230 peer-reviewed research articles. The proposed activities in this study logically build on my current and previous work in Microbiology, Molecular Biology, Bioinformatics, Human genetics and Genomics of Tuberculosis and other infectious diseases.